Clinical significance of HBV precore mutation and the quantities of HBV DNA in chronic hepatitis B virus infection

Objective To explore the clinical significance of HBV precore mutation and the quantities of HBV DNA in chronic hepatitis B virus infection. Methods HBV precore 1 896 mutation was detected in 116 patients with chronic HBV infection and the positive rates of precore mutation in different clinical groups were compared, and then the quantities of HBV DNA in different clinical groups were distinguished based on the same precore mutation. Results The positive rates of precore mutation in different clinical groups were no discrepancy(χ2=2.863,P=0.581).The chronic HBV carriers of positive precore mutation had higher HBV DNA(P=0.003) and there were no discrepancy in other groups.But it was possible that the quantities of HBV DNA decreased following the pathological prognosis in the same precore mutation. Conclusions Many factors can infect the pathological prognosis of HBV infection, it is possible that precore mutation is not one of those,but precore mutation may infect the replication of HBV DNA.