Observation on the Effect of Chinese Medicine of Shutangbao Oral Liquid on Diabetic Mouse Model

Objective To establish a mouse model of type 2 diabetes mellitus,and to observe the therapeutic effect of Chinese medicine of Shutangbao Oral Liquid on the model′s blood glucose level,blood lipid level and urea content.Methods Thirty-five Kunming mice were fed high-glucose and high-fat diet for four weeks,and then were injected with streptozotocin(STZ) by intraperitoneal approach to establish the mouse model of type 2 diabetes mellitus.The 35 mice were divided into three group randomly,model group,Shutangbao group and metformin group.Another 10 normal mice as control group.Shutangbao group was treated with Shutangbao Oral Liquid and metformin group with metformin by gavage,normal group and model group were treated with distilled water by gavage.The volumes of drinking water of the mice in each group were observed and recorded,and their blood glucose levels,total cholesterol(TC),triglyceride(TG) and urea content were detected before and after administration.Results The volumes of drinking water per day of the mice in Shutangbao group,and metformin group were less than those of control group,and model group after administration(P0.01);And the blood glucose levels and TG content of the mice in Shutangbao group,and metformin group were lower than those of model group(P0.01);Hypoglycemic rates were 42.50% and 35.09%,respectively.Conclusion Shutangbao Oral Liquid can significantly lower the blood glucose level,TG content and the volume of drinking water of mouse with type 2 diabetes mellitus.