Effects of Caragana sinica on Anti-fatigue in Mice

Objective: This experiment studies the anti-fatigue capability of water extracts from the roots of Caragana sinica in mice.Method: Take Kunming mice,and they are divided into control group and experimental group randomly.The experimental group is divided into three dose groups which are high dose group,medium dose group and low dose group(15,10,5 g·kg-1·d-1),and the three dose groups are irrigated the stomach with the drug individually;while the control group is given the same volume of distilled water.After 15 consecutive days,all the mice both in the control group and the experimental group are subjected to burden swimming and biochemical index detection.The time of the burden swimming was recorded.Meanwhile,half of the mice both in the control group and in the experimental group are measured about their the contents of blood lactic acid(LA),blood urea nitrogen(BUN) and liver glycogen(LG) after swimming without rest;while another half are measured after they rest for 30 min.Result: The water extracts from the roots of C.sinica could significantly increase the mice's ability of burden swimming,decrease the content of LA and BUN,and accelerate their clearance rate after exercise and increase the reserve and recovery rate of LG.Conclusion: Water extracts from the roots of C.sinica can significantly improve the anti-fatigue effects.