EFFECT OF RHODIOLA COMPOUND ON ANTI-FATIGUE ABILITY OF MICE

Objective To observe the effects of Rhodiola compound on anti-fatigue ability of mice,so asto provide experimental basis for furthaer application to military workers.Methods One hundred and sixty male Kunming mice were randomly divided into four groups(n = 40) for swimming test,serum urea assay,blood lactic assay,and liver glycogen assay respectively.Each group was again divided into the following four subgroups(n =10): low,middle,high dose groups of Rhodiola compound,and control group.The drug was given intragastrically at the dosage of0.12 g/kg,0.24 g/kg,and 0.72 g/kg(corresponding to 5,10 and 30 times respectively of the doses recommended to human) once daily for 30 d.Equal volume of distilled water was given to control group.Body weight,exhausted swimming time,serum urea level,blood lactate concentration,and hepatic glycogen content in Rhodiola compound treated groups were compared with those in the control.Results The swimming time was 63.6% more(P0.01),seram urea 17.8% less(P0.05),and blood lactatic curve area 8.6% less(P0.01) in high dose treated group than in control group.There were no significant differences in body weight and hepatic glycogen content among treated and control groups(P0.05).Conclusion Rhodiola compound has the effect of enhancing anti-fatigue ability of mice.