Expression of heat shock protein 70 in rats with acute spinal cord injury

Objective:To observe the expression of heat shock protein 70(HSP70) in rats with acute spinal cord injury.Methods:Fifty-six Wistar rats were randomly divided into 7 groups.Six groups were prepared into acute spinal cord injury models and the other group was used as control.The animal models of spinal cord injury were established at 2h,6h,12h,24h,48h and 72h respectively after injury.The HSP 70 expression in the spinal cord from each group at different time points was studied by method of west-blot.Results:The expression of HSP70 was already found at 2h after the spinal cord injury,reached the peak at 24h and lasted to the time point of 72h after injury.Conclusion:The HSP70 expression is the response of the body to stress.HSP70 is obviously increased in the gray nucleus of the spinal cord from 2h to 72 h after acute injury.HSP 70 may play a role in the prevention of the spinal cord from secondary lesion.