The Expression of Vascular Endothelial Growth Factor in Human Breast Cancer and Relationship to P53 Protein

Objective:To investigate the expression of vascular endothelial growth factor (VEGF) in breast cancer and its relationship to expression of P53 protein in breast cancer and to clinical pathological parameters. Methods:The expression of VEGF and P53 protein was detected by immunohistochemistry assay. Results:VEGF was expressed in 67.05% of primary breast cancer. The positive rate in lymph node metastasis group and non metastasis group was 94.29% and 49.06% respectively with significant difference ( P 0.001). Expression of VEGF in breast cancer had no relation to tumor size ( P 0.1). Expression of P53 protein was much higher in VEGF positive breast cancer than in VEGF negative ( P 0.01). Expression of P53 protein had no relation to tumor size ( P 0.5) and lymph node status ( P 0.1). Conclusion:Expression of VEGF may play a significant role in the development and metastasis of breast cancer. Deletion and mutation of P53 gene can decrease secretion of angiogenesis inhibitor and induce expression of VEGF in breast cancer. Deletion and mutation of P53 gene also play a role in the progression and metastasis in breast cancer.