Experimental Study about Preventing and Treating Effect of Electric Acupuncture Therapy on Rats with Diabetic Nephropathy

Objective:To investigate the preventing and treating effect of electric acupuncture therapy on rats with diabetic nephropathy.Methods:60 SD rats were used to establish diabetic nephropathy model by injecting STZ in abdominal cavity.Rats were divided into model control group,control group with western medicine and therapeutic group with electric acupuncture after the model was established.The normal control group was installed at the same time.The rats in every group were intervened respectively by normal saline,medicine and electric acupuncture stimulation.8 weeks later,several indexes in every rat,such as fasting blood glucose,glycosylhemoglobin,blood lipid,blood urea nitrogen,serum creatinine,urine minute albumin of 24 hours,and so on,were detected.The tissue of kidney in rats were collected and observed with optical microscope.Results:The levels of some indexes of rats in therapeutic group with electric acupuncture and control group with western medicine,such as serum total cholesterol,low density lipoprotein,blood urea nitrogen,serum creatinine,excretion rate of urine minute albumin,and so on,were lower than those in model control group significantly.The condition that glomerulus enlarged and mesangial cell proliferated were alleviated to some degree than that in model control group.Conclusion:The electric acupuncture therapy can improve the disorder of lipometabolism in rats with diabetic nephropathy and the abnormality of their renal function,and alleviate their pathological renal lesion to some degree,its preventing and treating function for diabetic nephropathy is equal to that of Benazepril.