Study on Protective Effect of Grape Seed Extract on Acute Liver Injury of Mice Caused by Alcohol

Objective To study the protective effect of grape seed extract against alcohol-induced acute liver injured.Methods Fifty Kunming mice were randomly divided into negative control group,acute liver injured group and different doses groups of grape seed extract.Different doses of grape seed extract were given to test groups by oral gavage,50% alcohol was given to mice by oral gavage once in order to make the acute liver injury model at the end of experiment.The contents of MDA,GSH and TG in hepatic tissue were detected.The livers of mice were detected by histopathology.Results The content of TG in high-dose group of grape seed extract was significantly lower than that in model control group,while the content of GSH was significantly higher than that in model control group,and the difference was statistically significant between the two groups(P0.05 or P0.01).The pathology changes of fat in hepatic tissue in high-dose group of grape seed extract were significantly less than those in model control group,and the difference was statistically significant between the two groups(P0.01).Conclusions Grape seed extract has the function of protecting the liver from acute injury induced by alcohol.