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2010•Central South PharmacyRequires access

Determination of imperatorin and isoimperatorin in Qingxuan tablets by HPLC

Zhang Shunzhi

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Abstract

Objective To establish an HPLC method for the determination of imperatorin and isoimperatorin in Qingxuan tablets.Methods HPLC method was used.The column was C18-A(200 mm×4.6 mm,5 μm).The mobile phase was methanol-water(55∶45),the flow rate was 1.0 mL·min-1,and the detective wavelength was 300 nm.Results The linear range of imperatorin and isoimperatorin was 0.015 1～0.135 9 and 0.010 5~0.094 5 μg.The average recovery was 99.6% and 100.6%,with RSD=0.56%(n=6) and RSD =1.92%(n=6).Conclusion The method can be used to detect imperatorin and isoimperatorin in Qingxuan tablets rapidly,accurately and conveniently,and control the quality of Qingxuan tablets.

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What this paper is about

Objective To establish an HPLC method for the determination of imperatorin and isoimperatorin in Qingxuan tablets.Methods HPLC method was used.The column was C18-A(200 mm×4.6 mm,5 μm).The mobile phase was methanol-water(55∶45),the flow rate was 1.0 mL·min-1,and the detective wavelength was 300 nm.Results The linear range of imperatorin and isoimperatorin was 0.015 1～0.135 9 and 0.010 5~0.094 5 μg.The average recovery was 99.6% and 100.6%,with RSD=0.56%(n=6) and RSD =1.92%(n=6).Conclusion The method can be used to detect imperatorin and isoimperatorin in Qingxuan tablets rapidly,accurately and conveniently,and control the quality of Qingxuan tablets.

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Available abstract

Objective To establish an HPLC method for the determination of imperatorin and isoimperatorin in Qingxuan tablets.Methods HPLC method was used.The column was C18-A(200 mm×4.6 mm,5 μm).The mobile phase was methanol-water(55∶45),the flow rate was 1.0 mL·min-1,and the detective wavelength was 300 nm.Results The linear range of imperatorin and isoimperatorin was 0.015 1～0.135 9 and 0.010 5~0.094 5 μg.The average recovery was 99.6% and 100.6%,with RSD=0.56%(n=6) and RSD =1.92%(n=6).Conclusion The method can be used to detect imperatorin and isoimperatorin in Qingxuan tablets rapidly,accurately and conveniently,and control the quality of Qingxuan tablets.

Key concepts: Imperatorin, Chromatography, Chemistry, High-performance liquid chromatography, Linear range, Detection limit

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