Comparative study of candesartan and benazepril in treatment of essential hypertension

AIM To compare the therapeutic effects of candesartan and benazepril in the treatment of essential hypertension.METHODS Fifty nine patients were treated with candesartan(8-16 mg/d) while fifty six patients were treated with benazepril(10-20 mg/d) for six weeks,and the results were compared.Blood pressure was monitored and blood lipid,urea nitrogen,creatinine, urine acid,blood α1-MG and urine α1-MG,urine Alb and plasma renin activity(PRA) were examined before and after the treatment.RESULTS Blood pressure monitoring showed no difference in the antihypertensive effect between the two drugs.Candesartan had no effect on TG and TC but it decreased the level of urine acid.The incidence of cough was lower in candesartan treated group.Candesartan also decreased blood α1-MG and urine α1-MG and urine Alb(P0.01),while plasma renin activity(PRA) increased(P0.01).CONCLUSION Candesartan is effective and safe in the treatment of hypertension and it can decrease the level of urine acid of blood.The incidence of cough is lower when candesartan is administrated.