Expression of Survivin and Caspase-3 protein and their correlation with prognosis in patients with cholangiocarcinoma

Objective To explore the expression of Survivin and Caspase-3 protein and their clinicopathological signi-cance in patients with cholangiocarcinoma.Methods The immunohistochemical method was used to analyze the Survivin and Caspase-3 protein expression in 57 cases of cholangiocarcinoma and 23 cases of adjacent noncancerous normal bile duct tissues.The correlation between the expression of Survivin and Caspase-3 protein with the clinicopathological features and prognosis were analyzed.Results The Survivin expression in cholangiocarcinoma was significantly higher than that in adjacent noncancerous normal bile duct tissues,but the Caspase-3 protein expression was on the contrary(both P0.05);the expression of Survivin and Caspase-3 protein were related with differentiation grade,TNM stage and lymphnode metastas(both P0.05);there was inverse correlation bewteen the expression of Survivin and Caspase-3 protein(P=0.001,r=-0.415);The kaplan-Meier analysis showed that the overall survival time of patients positively expressed Survivin was significantly shorter than that of patients negatively expressed Survivin,but the Caspase-3 protein expression was on the contrary(both P0.05);by Cox regression analysis,the Survivin expression was an independent prognostic factor(P0.05).Conclusions The high expression of Survivin and low expression of Caspase-3 protein may be a synergistic effect in the progression of cholangiocarcinoma.