Clinical analysis on omeprazole in treatment of functional dyspepsia

Objective To evaluate the efficacy and safety of omeprazole in treatment of functional dyspepsia.Methods 300 cases of functional dyspepsia were randomly allocated into 2 groups. The treatment group was treated with omeprazole 10 mg qd,and the control group was treated with domperidone 10 mg tid. The course of treatment in both groups was 4 weeks. The clinical symptoms such as heartburn,postprandial distention,epigastric pain and eructation as well as adverse reactions were observed.Results There was statistical significance in degree of improvement in clinical symptoms in comparison with pre and post treatment in these two groups (P0.05),the difference in scores of above-mentioned clinical symptoms between these two groups after treatment had no statistical significance (P0.05),but it was statistically significant in the occurrence of adverse reactions in these two groups.Conclusion The efficacy of omeprazole in treatment of functional dyspepsia is exact,and the efficacy of omeprazole is similar to domperidone,but the dosage of omeprazole is smaller with less adverse reactions. It is worthy to be recommended for clinical application.