2000•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access
Effect of ganquan 6 on mesenteric microcirculation in rats
Xing Guo
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Abstract
Aim To observe the effect of Ganquan 6 on mesenteric microcirculation in rats.Methods 21 Wistar rats were randomly divided into 3 groups (n=7). The first group served as the controled , the other two groups were orally given ganquan 6 at doses of 1.5 g·kg-1 and 3.0 g·kg-1 for 10 days. 30 minutes after the last administration,all the rats were injected 2 ml·kg-1 sterile amniotic fluid via lingualis vena.Results In the control group,amniotic fluid injection caused significant decreases in instant blood flow rate and blood flow (P0.05).In the ganquan 6 treated groups,although amniotic fluid injection failed to cause significant changes in microcirculation, the blood flow rate and blood flow had significant differences from those in the control group(P0.05,P0.01).Conclusion Ganquan 6 can improve the microcirculation in rats with microcirculatory disturbance caused by decreasing blood flow rate and blood flow and strengthen anoxia-tolerance of cells.