2008•Journal of Shantou University Medical CollegeRequires access
Effect of Eptithelial Cadherin in Invasion and Metastasis of Gastric Carcinoma
Li Wu
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Abstract
Objective:To investigate the expression of eptithelial cadherin(E-cad)in gastric carcinoma,and to study its effect in invasion and metastasis of gastric carcinoma.Methods:The immunohistochemistry was used to detect the expression of E-cad in 36 patients with gastric carcinoma.Results:The positive expression rate of E-cad(72.2%)in gastric carcinoma was lower than that in paracarcinoma mucosa(91.7%)(P0.05).There was a significant correlation between the positive expression and differentiation degree of E-cad(P0.05).Conclusion:The abnormal expression of E-cad plays an important role in the development of gastric carcinoma,and is involved in invasion and metastasis of gastric carcinoma.E-cad may be the useful marker to predict the clinical prognosis of patients with gastric carcinoma.