Effect of Penyanping Decoction Plus Pudi Decoction on Immune State and Cytokines of Chronic Pelvic Inflammation

Objective: To discuss the effect of Penyanping decoction plus Pudi decoction on the immunoregulation of patients with chronic pelvic inflammatory disease( hot and damp stasis junction). Method: One hundred and twenty patients were randomly divided into observation group( n = 60) and control group( n = 60). Control group was given Huangtengsu dispersible tablets after menstrual clean,4 tablets each time,3 time each day,for 20 days,matrine suppositories,1 capsule each time,1 time each day after menstrual clean for 3 days,for 20 days. Observation group was given Penyanping decoction after menstrual clean,200 mL each dosage, 1 dosage each day,all for 20 days,Pudi decoction,1 dosage each day after menstrual clean for 3 days,for 10 days. Both groups were observed for 3 menstrual cycle. Immune globulin G,immune globulin A,immune globulin M( IgG,IgA,IgM) of pretherapy and post-treatment were tested by rate nephelometry. Complement in blood serum( complement-C 3,complement-C 4) were measured by Single radil immunodiffusion. T lymphocyte subtype of CD+ 3,CD+ 4,CD+ 8 and CD+ 4 / CD+ 8 were detected by flow cytometry. The level of interleukin-2,interleukin-10, tumor necrosis factor-α( IL-2,IL-10,TNF-α) were tested. Result: The cases of abnormal IgG,IgA,IgM,C 3 and C 4 in observation group were less than control group( P 0. 05),the level of IgG,IgA,IgM of both groups after the treatment were lower than before,and the level of C 3,C 4 of both groups were higher than before( P 0. 05 or P 0. 01). The level of IgG in observation group were lower than control group,and the level of C 3,C 4 in observation group were higher than control group( P 0. 05 or P 0. 01). The cases of abnormal CD+ 3,CD+ 4, CD+ 8,CD+ 4 / CD+ 8 in observation group were less than control group( P 0. 05),the level of CD+ 3,CD+ 4,CD+ 4 / CD+ 8 in observation group were higher than control group,the level of CD+ 8 in observation group were lower than control group( P 0. 05 or P 0. 01). The level of IL-2,IL-10 of both groups were risen,and observation group were higher than control group,the level of TNF-α of both groups were declined,and observation group were lower than control group( P 0. 01). Conclusion: Penyanping decoction plus Pudi decoction can adjust humoral immunity,regulate T lymphocyte subtype and the level of inflammatory cytokines,promote equilibrium so as to be benefitial for disease rehabilitation. It may be significant mechanism of action.