A comparison of serum creatine kinase-MB and cardiac troponin I in patients undergoing CABG with off-pump technique or cardiopulmonary bypass

Objective: To examine the circulating levels of creatine kinase-MB and cardiac troponin I(cTnI) following coronary artery bypass graft(CABG) surgery by either standard cardiopulmonary bypass(CPB) or the ′octopus technique′ on a beating heart.Methods: Sixty patients with coronary heart disease(CHD) undergoing CABG surgery were randomly divided into two groups(n=30): the OPCABG group,which received off-pump CABG and the CPB-CABG group,which received CPB.Blood samples were obtained prior of the operation and at the 2nd,6th,24th h after the end of the operation.The serum creatine kinase-MB(CK-MB) and the cardiac troponin I(cTnI) were determined.Results: In both groups,the CK-MB and cTnI levels were significantly increased at the post-operative 2nd,6th,24th h compared with those before the operation(P0.01 or P0.05).Compared with those of the CPB-CABG group,the CK-MB and cTnI of the OPCABG group were markedly decreased at the 2nd,6th,24th h after the operation(P0.05).Conclusion: These data demonstrate that off-pump CABG has a greater protective effect on myocardial injury than CPB-CABG.