Myocardial Protective Function in Pre-operative Adapt to Post-local-ischemia in Pump Coronary Artery Bypass Grafting

Objective To investigate the myocardial protective function in pre-operative adapt to post-local-ischemia in pump coronary artery bypass grafting( CABG). Methods Seventy- two coronary heart disease( CHD) patients who had pump CABG in department of thoracic surgery,the First Affiliated Hospital of Wenzhou Medical University from August 2010 to August 2012 were divided randomly into groups study( n = 42),control( n = 30). The study group had adapt to post- local- ischemia before undergoing CABG( that cause myocardial ischemia in patients with preoperative topical,and then recover,then repeat several times after surgery),control group only had CABG. The levels of roponin I( cTnI),troponin T( cTnT),creatine kinase MB( CK- MB) were compared between 2 groups before operation and on days 1,3,5 after operation. Results There was significant difference of serum cTnI,cTnT,CK- MB levels between 2 groups in different time( P 0. 05). In group comparison,serum cTnI,cTnT levels were lower in study group than in control group on days 1,3,5 after operation. In intra- group comparison,levels of cTnI,cTnT higher on days 1,3,5 after operation than before operation between 2 groups( P 0. 05),and lower on days 5 than on days 1,3 in control group( P 0.05),but there was no difference between on days3 and on days 1( P 0. 05). The level of CK- MB was higher on days 3 after operation than before between 2 groups( P 0. 05),higher on days 3 than on days 1( P 0. 05). Conclusion Pre- operative adapt to post- local- ischemia,reducing the harm of CABG to patients,is of protective effects on myocardial tissues.