Assessing the effect of perindopril combined with bisoprolol on chronic congestive heart failure

Objective To observe and compare the effect of perindopril plus bisoprolol and perindopril on chronic congestive heart failure(CHF).Methods 75 cases of CHF were randomly divided into control group(group A,37 cases) and treatment group(group B,38 cases).Heart rate,blood pressure,heart function,LVDd,LVEF,CO,SV,A/E rate and FS between the two groups on the time point of before and after the treatment were compared.Results The blood pressure had declined significantly after treatment in the two groups(P0.01 ),the heart rate had declined significantly in group B compared with group A(P0.01).The heart function was improved significantly after treatment in the two groups(P0.01), and the improvement in group B was more significant than that in group A(P0.01 ).The LVDd didn' t show significant difference between the two groups at the time point of before and after treatment(P0.05).The A/E rate significantly declined after treatment in the two groups(P0.01 ),group B was better than that of group A(P0.01 ).CO and SV significantly improved after treatment both in the two groups(P0.01),but didn't show significant difference(P0.05 ) between the two groups.The LVEF significantly improved after treatment in the two groups(P0.01 ),and group B was better than that of group A(P0.05).Conclusion The treatment of combining perindopril and bisoprolol is more effective than only use perindopril in improving the prognosis of the patients with CHF.