Efficacy of budesonide inhalation treatment of 96 patients with COPD acute exacerbation

Objective To observe the therapeutic effect of inhaled budesonide aerosol on patients with acute phrase of chronic obstructive pulmonary disease. Methods 96 patients with chronic obstructive pulmonary disease of acute exacerbation from January 2009 to December 2012 in our hospital were chosen, who were randomly divided into observation group and control group, every group were 48 cases. Patients in control group were given oxygen, antibiotics, bronchodilators, phlegm, intravenous methylprednisolone 40 mg once a day. The patients in observation group were given additional budesonide inhalation, 2mg/time, 2 times/d. Results The indicators were observed before and after treatment, such as FEV 1, FEV 1 / FVC, PaO 2, PaCO 2,and so on. After one week treatments, pulmonary function PaO 2, PaCO 2, FEV 1, FEV 1 /FVC) were significantly improved than before treatment(P 0.01), and compared with the control group the observed group was above indexes significantly different(P 0.05). 19 cases of observation group were markedly effective in 25 cases, total effective rate was 91.7%; 14 cases of control group markedly effective in 23 cases, total effective rate was 77.1%. There was significant difference between the two groups(P 0. 05), with statistical significance. Conclusion This study illustrates that local and systemic corticosteroid drugs treatments of chronic obstructive pulmonary disease with acute exacerbation have significant clinical effect.