Effect of Salbutamol combined with budesonide in treatment of acute exacerbation phase of chronic obstructive pulmonary disease

Objective To evaluate the effect of salbutamol combined with budesonide in the treatment of acute exacerbation phase of chronic obstructive pulmonary disease (COPD).Methods A retrospective analysis was performed on 50 patients with acute exacerbation phase of COPD admitted to hospital from January 2010 to January 2011.The 50 patients were randomly divided into the study group and the control group by mechanical sampling,each with 25 cases.The control group received salbutamol inhalation plus conventional therapy,while the study group was treated by inhalation of salbutamol combined with budesonide based on conventional treatment.Both groups were treated for 10 days,and followed up for 1～2 weeks.The total effective rate (CR+ effective),PH,PaCO2,PaO2,FEV1/FVC,FEV% predicted,and blood gas changes before and after treatment in the two groups were compared.Results After treatment,the total effective rate (effective and markedly effective) in the study group was 92%,which is significantly higher than 76% in the control group (P0.05).Comparison within group showed that lung function and blood gas changes after treatment were significantly better than that before treatment (P0.05).Comparison between the two groups showed that all the indexes tested were significantly better than those in the control group (P0.05).Conclusion Salbutamol combined with budesonide was effective in treating acute exacerbation phase of COPD patients,by improving the prognosis and blood-like,which is worthy to be extended in clinical practice