Clinical study of the effect of hyperbaric oxygen therapy started at different time on patients with acute cerebral infarction

Objective To study the influence of different starting time of hyperbaric oxygen therapy on acute cerebral infarction. Methods According to the different therapy of hyperbaric oxygen, patients were randomly divided into 4 groups:super early hyperbaric oxygen treatment group(0~6 h), early hyperbaric oxygen treatment group(6 h~7 d), late hyperbaric oxygen treatment group(8~14 d) and control group.The control group was given traditional drugs and rehabilitation treatment of acute ischemic stroke.The super early hyperbaric oxygen treatment group, early hyperbaric oxygen treatment group and the late hyperbaric oxygen treatment group were given hyperbaric oxygen therapy. The therapeutic effect of each group was observed after treatment for 2 months. Statistical software SPSS19.0 was used for data analysis. Results After treatment, the scores of the neurological functional defects(NFD) in four groups were improved(P0.05), and the scores of NFD in the super early hyperbaric oxygen treatment group(10.10 ±8.473)were the lowest,the scores of NFD in the early hyperbaric oxygen treatment group(14.66±7.650) and the late hyperbaric oxygen treatment group were lower(18.92±6.471) than that in the control group(22.28±5.927); there were significant differences among the 4 groups. The effective rates of super early hyperbaric oxygen treatment group(0~6 h), early hyperbaric oxygen treatment group(6 h~7 d), late hyperbaric oxygen treatment group(8~14 d) and control group were 97.50%, 84.80%, 74.21%, 64.21%, respectively, showing no significant differences among the 4 groups(P0.05). The clinical effects of super early hyperbaric oxygen treatment group and early hyperbaric oxygen treatment group were better than the other groups, showing significant differences among the four group.Conclusion Hyperbaric oxygen treatment can significantly improve the restoration of disability in patients with acute cerebral infarction, and it was better for earlier treatment.