Observation on the Effect of Postoperative Radiotherapy Combined with Chemoradiotherapy in Treatment for Brain Gliomas

Objective:To explore the therapeutic efficacy of brain glioma treated with postoperative radiotherapy combined with temozolomide chemotherapy.Method:54 patients with WHO grade Ⅲ - Ⅳ gliomas from January 2008 to December 2010 were divided into group A and group B,with 27 patients in each group.Both groups were given radiotherapy after surgical resection of the tumor.Group B was given radiotherapy,group A was given temozolomide chemotherapy on the basis of radiotherapy.The short-term effect,survival and adverse reactions of two groups were compared.Result:The effective rate of group A(77.8%)was higher than that of group B(48.1%).The difference was statistically significant between the two groups( P 0.05). The one-year survival rates of the two groups showed no significant difference( P 0.05).The two-year survival rate of group A was 48.1%,which was higher than the 22.2% of group B,the difference was statistically significant( P 0.05).Compared the adverse reactions of group A with group B,the difference was not statistically significant( P 0.05).Conclusion:Postoperative radiotherapy combined with chemotherapy treating glioma can effectively improve the therapeutic effect and prolong the survival,should be widely applied.