Meta-analysis of temozolomide combined with radiotherapy in treatment of postoperative malignant glioma

Objective To compare the clinical effects and safety of brain malignant glioma treated with postoperative radiotherapy combined with Temozolomide chemotherapy and with radiotherapy only. Methods By searching CNKI,CBM,Pubmed、Medline,the studies were included if they were in accordance with inclusion criteria. Data were extracted and evaluated by two reviewers independently and data were analyzed using RevMan 5. 0. Results 8studies were included with a total of 418 patients. Meta-analysis results were as follows:The total effective rate of the test group received postoperative radiotherapy combined with temozolomide chemotherapy was higher than that in the control group received radiotherapy only,the difference was statistically significant(OR = 3. 42,95% CI:2. 09 ~ 5. 58,P 0. 000 01);The one-year、two-year and three-year survival rate of study group were higher than those in the control group,the difference was statistically significant(one-year survival rate:OR = 2. 99,95% CI:1. 85 ~ 4. 84,P 0. 00001;two-year survival rate:OR = 4. 52,95% CI:2. 55 ~ 8. 01,P 0. 000 01;three-year survival rate:OR = 4. 41,95% CI:1. 83 ~ 10. 64,P = 0. 001 0);The main side-effects were nausea,vomiting,myelosuppression and headache. There were no significant diferences between the two groups,P 0. 05. Conclusion The clinical effects of brain malignant glioma treated with postoperative radiotherapy combined with temozolomide chemotherapy was higher than with radiotherapy only,and there were no significant adverse reactions. In that case,it is worthy to be popularized.