Expressions of HSP27 in lung carcinoma and its clinical implication

【Objective】To determine the expression of HSP27 (heat shock protein 27, a member of heat shock protein family) in lung carcinoma and investigate the relationship between HSP27 expression and invasion of lung carcinoma. 【Methods】 Immunohistochemical staining was used to detect the expression of HSP27 in 63 cases of lung carcinoma, 21 cases of benign tumor and 22 cases of normal lung tissue to analyze the relationship between their expression and various clinic pathologic factors of lung carcinoma. 【Results】None of the normal intestinal tissues and benign tumor were HSP27 positive. In 63 lung carcinoma specimens, the positive expression rate of HSP27 was 63.5% (40/63). HSP27 expression correlated with the degree of tumor differentiation and tumor metastasis (P 0.05). But not related to some clinic pathological characteristics such as the age, sex and size. 【Conclusions】The expression of HSP27 in tumor tissue may be a new marker of the biological behavior of lung carcinoma.