Test and Analysis of Serum High Sensitive C-reactive Protein in Patients with Type 2 Diabetic Nephropathy

Objective To compare serum high sensitive C-reactive protein(hs-CRP)levels in Type 2 diabetes mellitus(T2DM)and type 2 diabetic nephropathy.Methods All patients were divided into three groups:Group A[DM(+),UAlb30 mg/24 h,n=32],Group B[DM(+),UAlb≥30 mg/24 h,n=30],Group C[Normal health subjects,n=30].The serum hs-CRP,insulin,glucose,total cholesterol,HDL-CHO,LDL-CHO,TG,HbA1C and Homeostasis model assessment for insulin resistance(HOMA IR)index were determined.Results The mean hs-CRP levels of Group A and Group B were higher than that of Group C(P0.01);Mean hs-CRP levels of Group B was higher than that of Group A(P0.05).The hs-CRP levels of Type 2 diabetic has a positive correlation with HbA1C,fasting insulin and HOMA-IR.Conclusions Increased level of serum CRP may correlate with type 2 diabetes and its angiopathy.There was positive correlation between serum hs-CRP and HbA1c,fasting insulin and HOMA-IR in patients with T2DM.The inflammation,hyperglycaemia and insulin resistance contribute jointly to angiopathy in T2DM patients.