Association between glycosylated hemoglobin and glucose fluctuation in patients with type 2 diabetes mellitus

Objective To investigate the association between glycosylated hemoglobin(HbA1c) and glucose fluctuation in patients with type 2 diabetes mellitus(T2DM).Methods Continuous glucose monitoring system(CGMS) was applied to monitor glucose level for 3 days in 120 patients and HbA1c was also measured.All the patients were divided into three groups according to the level of blood glucose fluctuation coefficient(BGFC)(group 1: BGFC≤1.5; group 2: 1.5BGFC3.0;group 3: BGFC≥3.0).Results Mean blood glucose(MBG),mean fasting blood glucose(MFBG),high glucose(≥11.1 mmol/L) duration ratio(Ab11.1) and low glucose(≤3.9 mmol/L) duration ratio(Be3.9) were significantly different among groups(P0.01).The level of HbA1c increased with the increment of BGFC and differences observed among groups was statistical significance(P0.05).Conclusion Blood glucosefluctuation is positively associated with HbA1c in patients with T2DM.