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2011•Chinese Journal of Spectroscopy LaboratoryRequires access

Determination of Domperidone in Human Plasma by HPLC-MS/MS

Ya Hong Luo

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Abstract

The concentration of domperidone in human plasma was determined by HPLC-MS/MS.The samples were separated by Luna C18 column(150mm×2mm,5μm).The mobile phase was consisted of methanol∶water(0.4% ammonium acetate)(85∶15,V/V).The detection was performed in SRM.There was a good linear relationship for domperidone concentration in the range of 0.5—100ng/mL,and the standard deviation of inter-day,intra-day and accuracy were all less than 10%.This method is sensitive,accurate and fast,which is used for the determination of domperidone in human plasma.

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What this paper is about

The concentration of domperidone in human plasma was determined by HPLC-MS/MS.The samples were separated by Luna C18 column(150mm×2mm,5μm).The mobile phase was consisted of methanol∶water(0.4% ammonium acetate)(85∶15,V/V).The detection was performed in SRM.There was a good linear relationship for domperidone concentration in the range of 0.5—100ng/mL,and the standard deviation of inter-day,intra-day and accuracy were all less than 10%.This method is sensitive,accurate and fast,which is used for the determination of domperidone in human plasma.

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Available abstract

The concentration of domperidone in human plasma was determined by HPLC-MS/MS.The samples were separated by Luna C18 column(150mm×2mm,5μm).The mobile phase was consisted of methanol∶water(0.4% ammonium acetate)(85∶15,V/V).The detection was performed in SRM.There was a good linear relationship for domperidone concentration in the range of 0.5—100ng/mL,and the standard deviation of inter-day,intra-day and accuracy were all less than 10%.This method is sensitive,accurate and fast,which is used for the determination of domperidone in human plasma.

Key concepts: Domperidone, Chromatography, Human plasma, Chemistry, Ammonium acetate, High-performance liquid chromatography, Relative standard deviation, Detection limit

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