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Induction of Apoptosis of Bladder Cancer Cell Line EJ By Tea Polyphenols

Guo Gang Feng, Jun Zhang, Hongjun Shi, Yan Zhao

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Abstract

Objective To study the induction of apoptosis of bladder cancer cell line EJ by tea polyphenols in vitro.Methods Inhibition of EJ cell culture by different concentrations of polyphenols was observed by EJ cell growth activity.Apoptosis was detected by DNA gel electrophoresis, light microscope photography.Results After the BJ cells were treated by tea polyphenols in vitro,it was shown that the growth of EJ cells was inhibited.DNA ladder was viewed on agarose gel of 1.0% concentration.Typical cell apoptosis structure,nuclear condensation and fragmentation were observed at 36 th hour after.Conclusion Polyphenols of tea does have an effect on inhibiting and killing of EJ cells,and one of its mechanism is proposed partially by inducing apoptosis.

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What this paper is about

Objective To study the induction of apoptosis of bladder cancer cell line EJ by tea polyphenols in vitro.Methods Inhibition of EJ cell culture by different concentrations of polyphenols was observed by EJ cell growth activity.Apoptosis was detected by DNA gel electrophoresis, light microscope photography.Results After the BJ cells were treated by tea polyphenols in vitro,it was shown that the growth of EJ cells was inhibited.DNA ladder was viewed on agarose gel of 1.0% concentration.Typical cell apoptosis structure,nuclear condensation and fragmentation were observed at 36 th hour after.Conclusion Polyphenols of tea does have an effect on inhibiting and killing of EJ cells,and one of its mechanism is proposed partially by inducing apoptosis.

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Available abstract

Objective To study the induction of apoptosis of bladder cancer cell line EJ by tea polyphenols in vitro.Methods Inhibition of EJ cell culture by different concentrations of polyphenols was observed by EJ cell growth activity.Apoptosis was detected by DNA gel electrophoresis, light microscope photography.Results After the BJ cells were treated by tea polyphenols in vitro,it was shown that the growth of EJ cells was inhibited.DNA ladder was viewed on agarose gel of 1.0% concentration.Typical cell apoptosis structure,nuclear condensation and fragmentation were observed at 36 th hour after.Conclusion Polyphenols of tea does have an effect on inhibiting and killing of EJ cells,and one of its mechanism is proposed partially by inducing apoptosis.

Key concepts: Apoptosis, Polyphenol, Agarose gel electrophoresis, DNA fragmentation, Fragmentation (computing), In vitro, Cell culture, Cell

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