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Dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes

Xin Hu

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Abstract

The present paper summarized the dipeptidyl peptidase Ⅳ(DPP-Ⅳ) and the clinical studies of DPP-Ⅳ inhibitors.DPP-Ⅳ reduces the degradation of GLP-1 and GIP,which stimulate insulin secretion.Inhibition of plasma DPP-Ⅳ enzyme leads to enhance endogenous GLP-1 and GIP activity,which ultimately results in insulin secretion and lowers the blood glucose level.

About this research paper

What this paper is about

The present paper summarized the dipeptidyl peptidase Ⅳ(DPP-Ⅳ) and the clinical studies of DPP-Ⅳ inhibitors.DPP-Ⅳ reduces the degradation of GLP-1 and GIP,which stimulate insulin secretion.Inhibition of plasma DPP-Ⅳ enzyme leads to enhance endogenous GLP-1 and GIP activity,which ultimately results in insulin secretion and lowers the blood glucose level.

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Available abstract

The present paper summarized the dipeptidyl peptidase Ⅳ(DPP-Ⅳ) and the clinical studies of DPP-Ⅳ inhibitors.DPP-Ⅳ reduces the degradation of GLP-1 and GIP,which stimulate insulin secretion.Inhibition of plasma DPP-Ⅳ enzyme leads to enhance endogenous GLP-1 and GIP activity,which ultimately results in insulin secretion and lowers the blood glucose level.

Key concepts: Dipeptidyl peptidase, Dipeptidyl peptidase-4, Secretion, Type 2 diabetes, Endogeny, Endocrinology, Internal medicine, Insulin

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