Dipeptidyl peptidase-IV (DPP-IV) Inhibitors – a promising oral anti-diabetic drug

Dipeptidyl-peptidase IV (DPP-4) inhibitors inhibit the degradation of the incretins i.e glucagon-like peptide1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Incretins augment the insulin release by a blood glucose-dependent mechanism. Generally DPP-IV enzyme is responsible for inactivating incretins and this enzyme inhibition will prolong and enhance the activity of GLP-1 and GIP. DPP-IV inhibitors increase post prandial insulin secretion, decreases glucagon secretion and seems to have beneficial effect on cardiovascular system, renal and hepatic insufficiencies. Being safe, tolerable and able to maintain consistent glycemic control without severe hypoglycemia and weight gain makes it unique and valuable in pharmacotherapy of Type 2 diabetes mellitus. Keywords: Dipeptidyl peptidase IV inhibition, incretin, gliptin, oral antidiabetic drugs, Type-2 diabetes mellitus Cite this Article S. Manak, F. Akram, D. Inder. Dipeptidyl peptidase-IV (DPP-IV) Inhibitors – a promising oral anti-diabetic drug. Research & Reviews: A Journal Pharmaceutical Science . 2020; 11(3): 1–6p.