2006•Chinese Journal of Public HealthRequires access
Effect of daidzein on activity of GSH-Px and content of MDA in heat-stressed mice
Gao Fen
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Abstract
Objective To investigate the effect of daidzein on activity of glutathione peroxidase(GSH-Px) and content of malondialdehyde(MDA) in heat-stressed mice.Methods Thirty mice were randomly divided into three groups:the control group,the heat-stressed group and the heatstressed group supplemented with daidzein.The mice were examined in terms of changes of activity of GSH-Px and content of MDA in liver,spleen,kidney and serum after being heat-stressed under the condition of(45±1)?℃ for twenty minutes.Results Compared with the control group,the activity of GSH-Px in liver,spleen and kidney in heat-stressed group increased,and there was significant difference in the result of liver(P0.05).The activity of GSH-Px in the daidzein group increased significantly compared with the control(P0.05 or P0.01).The activity of liver and spleen in the daidzein group increased significantly compared with that in the heat-stressed group(P0.05).The contents of MDA in two heat-stressed groups both increased compared with that in the control group,and there were significant differences in the result of liver and serum(P0.05).The MDA content in daidzein group was slightly less than that in heat-stressed group,but no statistical significance(P0.05) was found.Conclusion Daidzein can increase the activity of antioxidation in heat-stressed mice.