Effects of Baicalin on Anti-oxidation Function in Liver of Liver Injury Mice

Objective: To observe the effects of baicalin injection on anti-oxidation function in mice liver of the acute liver injury induced by carbon tetrachloride(CCl4).Method: 50 mice were randomly divided into five groups,10 mice every group,while the groups were the control group,the model group,and the baicalin groups at low,middle and high doses(0.25g/kg,0.50g/kg,1.00g/kg) respectively.The acute liver injury model of mice were induced by CCl4,the body weight,the liver index,the activity of SOD and GSH-Px,and the content of GSH and MDA of mice were determined.Results: There were not significant differences(P0.05) of the body weight and the liver index of mice among five groups.Comparing with the model group,the activity of SOD and GSH-Px,and the content of MDA in liver of mice,which in the baicalin group at low dose,were not significantly differences(P0.05),but the content of GSH increased significantly(P0.05).Comparing with the model group,the activity of SOD and GSH-Px in liver of mice,which in the baicalin groups at middle and high doses,increased very significantly(P0.01),the content of GSH increased very significantly(P0.01),and the content of MDA decreased very significantly(P0.01).Conclusion: Baicalin could significantly increase the activity of SOD and GSH-Px in liver of mice with acute liver injury,increase the content of GSH,and decrease the content of MDA,and there was a positive relationship between dose and effect.