Study of Expression of Survivin and COX-2 in Esophageal Squamous Carcinoma and Their Relationship

Objective To detect the expression of inhibitor gene of apoptosis,survivin,in esopheagal squamous carcinoma(ESC) and analysis its relationship with COX-2.Methods The expression of survivin and COX-2 in 68 cases in ESC and 15 no mal esophageal tissues were detected by immunohistochemistry(the method of streptoridin-peroxidase,SP).Results In contrast to negative expression in no mal esophageal mucosa,survivin expressed in 45 of 68 cases of ESC samples.COX-2 protein expressed in 54 of 68(79.4%).There were no relationship among survivin expression and age,sex,and tumor location .There were relationship between survivin gene expression and degree of differentiation,lymph node metastasis.The expression of survivin was positively correlated with that of COX-2.Conclusion The specific up regulation of survivin in ESC suggests that survivin may play an important role in the process of carcinoma genesis.It was speculated that there may be a common transcription mechnism which constructed multiple pathways.