Relationship between the plasm level of homocysteine and C-reaction protein and carotic intimal-medial thickness in patients with type 2 diabetes

Objective: To explore the relationship between the plasm level of homocysteine(Hcy) and C-reaction protein(CRP) level and carotic intimal-medial thickness(IMT) in patients with type 2 diabetes(T2DM).Methods: Forty-five patients with preliminary diagnosis of T2DM were divided into the two groups according to IMT level: the normal IMT group and the IMT-increased group.Thirty-two healthy cases were chosen as the control.All patients and the control were detected with Hcy,CRP,total cholesterol(TC) and triglyceride(TG).Results: Hcy and CRP levels in T2DM were higher than those in the controls(P0.05).Hcy and CRP levels in the group with increased IMT were higher than those in the normal IMT group(P0.05).The positive correlation between Hcy,CRP levels and IMT was shown(P0.01),so was the correlation between Hcy levels and CRP levels(P0.05).Conclusion: Hcy and CRP levels may take part in the inflammation process of AS and may predict the early stage of AS in T2DM clinically.