Clinical Observation of Ademetionine Therapy for Hyperbilirubinemia-virus Hepatitis in 108 Cases

Objective To observe the therapeutic effect of Ademetionine in treating hyperbilirubinemia-virus hepatitis.Metbods 214 cases of hyperbilirubinemia-virus hepatitis patients(whose serum total bilirubin(STB)more than 171 μmoL/L)were randomly divided into treatment group(n=108)and control group(n=106).The same basic therapy was applied to the two groups.Ademetionine was given to the treatment group with a dosage of 1 000 mg intravenous drip once a day for 4 weeks.The therapeutic effect on patients in the two groups were compared.Results The efficiency for the dermato pruritus,fatigue or anorexia in treatment group was better than control group(P 0.05).For Acute icteric hepatitis(AIH)and Severe chronic hepatitis(SCH) patients,the efficiency for liver function returning to normal and the total efficiency in treatment group were higher than control group(P 0.05).The time for the liver function returning to normal for AIH and SCH in the treatment group were shorter than that of the control group(P 0.05).For AIH and SCH patients,The degree of STB declined in the treatment group were more than that of the control group(P 0.05).For Subacute hepatitis gravis(SHG)and chronic hepatitis gravis(CHG)patients,there was no difference between treatment group and control group.No side effect related to Ademetionine was found.Conclusions Ademetionine is an effective assistant drug for the treatment of AIH and SCH.It can also be used to alleviate clinical symptoms(the dermatopruritus,fatigue and anorexia)of patients with SHG and CHG.