Clinical observation of Ursodeoxycholic acid combining Ademetionine in treatment of viral hepatitis E patients with severe jaundice

OBJECTIVE To observe the efficacy of Ursodeoxycholic acid(Ursofalk) combining Ademetionine(Transmetil) in the treatment of viral hepatitis E patients with severe jaundice.METHODS 97 cases of acute viral hepatitis E with severe jaundice were randomly divided into A,B and C groups.The patients of group A were given Ademetionine 1000～1500mg qd.The patients of group B were given Ademetionine 1000～1500mg qd and Ursodeoxycholic acid 250mg bid.The patients of group C were given Potassium magnessium aspartape 30mL qd.The duration of treatment was 4 weeks.RESULTS After 4 weeks' treatment,the T-BiL,ALT,ALP and γ-GT of Group B patients were lower than that of the other two groups.The total effective rate in the group B was significantly higher than that in group A and group C(85.7% vs 72.5% and 51.3%,P0.05 and P0.01).CONCLUSION Compound Ursodeoxycholic acid plus Ademetionine is effective in the treatment of viral hepatitis E patients with severe jaundice.Treatment of either group was effective,but was more effective for the combined group.