Effect of Concurrent Conformal Radiotherapy and Chemotherapy for Locally Advanced Gastric Cancer

[Purpose] To investigate the short-term response and toxicity of concurrent conformal radiotherapy and chemotherapy for locally advanced gastric cancer.[Methods] Thirty-six cases with locally advanced gastric cancer were divided into treatment group and control group.The treatment group(17 cases) received FOLFOX4 regimen chemotherapy and concurrent three-dimensional conformal radiotherapy(total doses 45~50 Gy),and the control group(19 cases),with the same regimen chemothera-py alone as the treatment group.[Results] All the 36 patients completed the treatment,with short-term response rate(RR) 76.5% and 42.1%,disease control rate(DCR) 88.2% and 57.9% in the treatment group and control group respectively.There was significant difference in RR or DCR between the two groups(P0.05).There was no significant difference between the two groups in the digestive tract toxicity,myelosuppression,peripheral neuritis(P0.05).[Conclusion] Concurrent conformal radiotherapy and chemotherapy for locally advanced gastric cancer is effective,and its toxicities are tolerable.