Pharmacokinetic Study of Serum Schizandrin in Wuchai Particles in mice

Objective To study pharmacokinetics of schizandrinin in Wuchai Particles in mice.Methods After oral administration of Wuchai Particles(2 g/kg) for the mice,the serum was collected at different time points.The components in the Wuchai Particles and serum were analyzed by HPLC to monitor the changes of the schizandrin in serum so as to draw the curve of concentration connected with time.Results The main component in Wuchai Particles was schizandrin;after oral administration of Wuchai Particles,the schizandrin in serum of mice was detected.The mean concentration of schizandrinin was 1.07,1.14,0.59,0.51 μg/ml respectively at five,ten,twenty,thirty minutes in serum.Conclusion The schizandrin in Wuchai Particles could be absorbed in mice after oral administration.It could be absorbed and eliminated rapidly.The pharmacokinetics of schizandrin in serum complies with linear kinetic course.