Pharmacokinetic Study of Schisandrin in Shengmai Powders

Objective To study the pharmacokinetics of schizandrin in Shengmai powders in normal rats.MethodsAfter ig administration of the drug(2.16 g/kg)for the rats,the plasma was collected at different time points.The schizandrin in Shengmai powders and in the plasma were analyzed by HPLC.Pharmaconetic parameters were calculated from the plasma concentration-time data with the 3p97 software package.ResultsThe main pharmacokinetic parameters were as follows:t1/2(Ka) was 0.245 hour,t1/2(Ke) was 1.506 hour,T(peak) was 0.767 hour,Cmax was 0.926 mg·L-1,AUC was 2.863 mg·L-1·h-1.ConclusionThe schizandrin in Shengmai powders can be absorbed into body,and its absorption and elimination is rapid.The pharmaconetics of plasma schizandrin complies with linear kinetic course.