Pharmacokinetic Study of Schizandrin in Wuling Capsules in Mice

Objective:To investigated the law of Chinese traditional medicine formula in vivo dynamic course effects to the pharmacodynamic.Methods:The schizandrin and Wuling capsules were given to mice individualy by irrigate stomach, the blood plasma was collected in dissimilarity time, the sample fluid was prepared to extract adding amine sulfate and mix fluid of Acetonitrile-methyl alcohol (4∶1), and which to be detected content of schizandrin by HPLC.Results:After irrigated the drugs to mice, the plasma concentration-time course fitted well to one-compartment model with the 1st order absorption and with the following pharmacokinetic parameters:the parameter of schizandrin were Ka=1.56 1/h,Ke= 0.51 1/hT Max= 1.05 h,T 1/2ke=1.33 h; the parameter schizandrin of Wuling capsules in stomach were Ka=1.89 1/h,Ke=0.25 1/h,T Max=1.25 h,T 1/2ke=2.71 h; those in intestinal were Ka=14.63 h,Ke=0.25 h,T (Max)=3.65 h,T 1/2ke=2.71 h.Conclusion:The formula of Chinese traditional medicine changes the character of biopharmaceutics of mostly chemical components in Chinese medicine in vivo. The effect of pharmacodynamic prolongs and the bioavailability increases.