Effect and safety of combined medication for the treatment of mild to moderate essential hypertension

Objective To investigate the efficacy and safety of Fosinopril plus hydrochlorothiazide in patients with mild to moderate essential hypertension.Methods 32 patients with mild to moderate hypertension orally received Fosinopril 10 mg/d and hydrochlorothiazide 25 mg/d.The course of therapy was designed as long as 16-weeks.Statistical analysis was performed after a series of indices including ABPM,blood glucose,blood lipid and uric acid detected before and after treatment.Results A gradual decrease of blood pressure and heart rate was observed from 1 to 8 weeks.The effective rate was 43%,71.5%,91.3% at 2-week,4-week,and 8-week course of therapy respectively.There was a significant decrease in the levels of 24h MSBP,blood pressure load and 24h PP compared with the same indices before treatment(P 0.05).Adipper curve of ABPM was found after treatment.The T/P levels of SBP and DBP were 0.83 and 0.92 respectively,while the SI levels of SBP and DBP were 3.01 and 2.97 respectively.No metabolic parameters changes were observed after treatment.Conclusion Fosinopril plus hydrochlorothiazide can decrease 24 h blood pressure smoothly and safely.