2015•China Medical HeraldRequires access
Meaning on pepsinogen andtumor markers joint detection in the diagnosis for elderly patients with gastric cancer
DU Jua
Open publisher page 0 citations
Abstract
Objective To discuss the meaning on pepsinogen and tumor markers joint detection in the diagnosis for elderly patients with gastric cancer. Methods From November 2012 to October 2014, in Tumor Hospital of Jilin Province,150 elderly patients(≥65 yares) with gastric disease were selected, 50 patients were gastric cancer(gastric cancer group),50 patients were gastric ulcer(gastric ulcer group), 50 patients were superficial gastritis(superficial gastritis group). PGⅠ,PGⅡ in serum were detected by ELISA. CEA, CA199 and CA242 were detected by chemiluminescence. The sensibility and specificity of single detection and joint detection of PGR(PGⅠ/PGⅡ), CEA, CA199 and CA242 were calculated and compared. Results PGⅠ, PGⅡ, CEA, CA199 and CA724 in serum, PGR of three groups were compared, the differences were statistically significant(P 0.05). Compared with superficial gastritis group, in gastric cancer group,PGⅠ, PGR reduced(P 0.05), the difference of PG Ⅱ between two groups was not statistically significant(P 0.05),CEA, CA199, CA742 increased(P 0.05); in gastric ulcer group, PGⅠ, PGⅡincreased(P 0.05),PGR reduced(P 0.05). Compared with gastric ulcer group, in gastric cancer group, PGⅠ, PGⅡ,PGR reduced(P 0.05), CEA, CA199,CA742 increased(P 0.05). The sensibility of united detection(68%, 34/50) was higher than that of single detection,the differences were statistically significant(P 0.05). Conclusion The pepsinogen and tumor markers joint detection is helpful on diagnosis for elderly patients with gastric cancer, and united detection is better than single detection.