Relationship between serum albumin level and severity of coronary heart disease

Objective:To investigate the relationship between serum albumin level and severity of coronary heart disease(CHD).Methods:A total of 237 patients admitted in our hospital from 2008 to 2009 and undergoing coronary angiography were enrolled.CHD severity was evaluated according to clinical types,number of diseased coronary vessels and coronary artery score respectively,and patients were divided into non-CHD group(n=84),angina pectoris group(n=92) and myocardial infarction group(n=61).Serum total protein,albumin and globulin were measured in all patients on second day after admission.Relationship among indexes of CHD severity and serum proteins were analyzed.Results:Compared with non-CHD group,there was significant decrease in albumin level [(40.22±3.56) g/L vs.(39.81±3.56) g/L vs.(38.68±3.43) g/L,P0.05] in angina pectoris group and myocardial infarction group.Spearman correlation analysis indicated that serum albumin level was significant negatively correlated with clinical types(r=-0.18,P=0.005),number of diseased coronary vessels(r=-0.195,P=0.003) and coronary artery score(r=-0.188,P=0.004).Serum total protein,globulin and ratio of albumin/globulin were not significantly correlated with clinical types,number of diseased coronary vessels and coronary artery score(P0.05).Conclusion:Serum albumin level is negatively correlated with severity of coronary heart disease.Low serum albumin may be a risk factor for coronary heart disease.