Changes of bone mineral density and related factors in type 2 diabetic patients

Objective To investigate the changes of bone mineral density(BMD) in type 2 diabetic patients and the possible factors involved in. Methods Dual energy X ray absorptiometry was used to determine the BMD of lumbar spines(L 2-4 ), femoral neck, Ward's triangle, and trochanter. Fasting blood glucose(FBG), postprandial blood glucose(PBG), fasting insulin(F1NS), postprandial insulin(PINS), fasting C petide(FCP),and urine albumin exeretion rate (UAER) were also measured. Results Compared with normal group, the BMD of L 4 in male diabetic patients significantly decreased, the BMD of L 2-4 , Ward's triangle and trochanter in female diabetic patients significantly decreased. Multivariate regression analysis showed that the changes of BMD were significantly correlated with FCP, UAER for male and female diabetic patients; meanwhile, the changes of BMD were significantly correlated with duration of disease for male diabetic patients and the years after menopause for female diabetic patients. Conclusion BMD significantly decreases in type 2 diabetic patients, to greater extent in female diabetic patients than in male diabetic patients. Islet cell hypofunction and increasied UAER are relatied to decrease of BMD.\;