Changes of Serum Levels of Inflammatory Factors in Multiple Myeloma and Their Clinical Significances

Objective To investigate the changes of serum levels of inflammatory factors in multiple myeloma(MM) and their clinical significances.Methods The ELISA method was employed to measure the serum levels of interleukin-6(IL-6) and tumor necrosis factor-alpha(TNF-α) between 150 MM patients(MM group) and 50 healthy controls(control group),and latex-enhanced immunity transmission turbidity method was used for the measurement of serum high-sensitivity C-reactive protein(hsCRP).And the associations between above three indices were analyzed.Results The serum levles of IL-6,TNF-αand hsCRP were markedly higher in the MM group than in the control group,and they were increased significantly with increasing clinical stage,demonstrating considerable differences between varying stages(P0.01).In serum of MM patients,IL-6 was directly related to hsCRP(γ=0.546,P0.01) as well as TNF-α(γ=0.711,P0.01),and TNF-αpositively correlated with hsCRP(γ=0.568,P0.01).The serum levels of IL-6,TNF-αand hsCRP were substantially reduced in the groups of potent therapy for MM after treatment when compared with those before treatment,all P0.01(t=9.770,3.448,and 18.390 respectively),while no significant alterations were noted before and after treatment in the group of ineffective therapy(P0.05).Conclusion Measurement of the serum inflammatory factors aided in judging disease condition and monitoring their efficacies in MM patients.