2014•Unpublished venueRequires access
Changes of IL-33 and IL-6 level in patients with multiple myeloma and their clinical significance
Gao Shu-y
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Abstract
Objective To detect the serum levels of IL-33 and IL-6 in patients with multiple myeloma, and to explore their role in disease development. Methods From Jan. 2012 to Jan. 2013, 37 patients of multiple myeloma(MM) and 50 healthy controls were selected as the research objects. ELISA was used to detect the serum levels of IL-33 and IL-6. Data were statistically analyzed. Results The detection rate of IL-33 showed no statistically significant difference between the two groups. IL-33 levels were negatively correlated with MM stage, and IL-33 levels of MM patients decreased significantly compared with healthy controls(P0.05). IL-6 levels were positively correlated with MM stage, and IL-6 level of MM patients increased significantly compared with healthy controls(P 0.05). Conclusion Changes in IL-33 and IL-6 levels may promote the progress of MM by adjusting the cellular immunity, and maintaining the balance of T cell subgroup may contribute to the treatment of myeloma disease.