Changes of CD5~+ B cell and CD4/CD8 T cell ratio in patients with chronic hepatitis B

Objective To study the role of CD5+ B cells and the ratio of CD4/CD8 in the pathogenic mechanism of chronic hepatitis B.Methods The percentages of CD5+ B cell(CD5+ CD19+) and the ratio of CD4/CD8 in 48 patients with chronic hepatitis B and 37 healthy control were determined using immunofluorescence double-staining and flow cytometry.Results The CD4/CD8 ratio was significantly increased in chronic hepatitis B patients during hepatitis exacerbation compared with subsequent convalescence,and healthy controls.The percentages of CD5+ B cell was significantly increased in chronic hepatitis B patients during hepatitis exacerbation compared with that in healthy controls,but not in convalescence stage of the patients.Conclusion The development of hepatitis B was connected with the derangement of T lymphocytes closely,and CD5+ B cell may play a role in protracted course of disease.