Expression of VEGF and its clinical significance in ovarian endometriosis

Objective To investigate the significance of expression of vascular endothelial growth factor(VEGF) in ovarian endometriosis(EMs).Methods Imunohistochemical staining and stereology methods were used to detect the VEGF and MVD in ectopic endometrium of 30 cases,in eutopic endometrium of 30 cases of ovarian endometriosis and normal endometrium in 30 cases.Results The mean optical density of VEGF in eutopic endometrium of endometriosis(0.47±0.12) was significantly higher than that in ectopic endometrium of endometriosis(0.32±0.08) and the normal control(0.39±0.14).The MVD in ectopic endometrium of endometriosis(41.58±14.72) was significantly higher than that in eutopic endometrium of endometriosis(31.30±19.89) and the normal control(20.70±16.17).The expressions of VEGF in secretary phase eutopic endometrium of endometriosis and the normal control were significantly higher than that in the proliferative phase(P0.05).VEGF and MVD had an obviously positive correlation in endometriosis and the normal control,and the positive correlation of VEGF and MVD in eutopic endometrium of endometriosis was higher than that in ectopic endometrium of endometriosis.Conclusion It suggested that there was a prerequisite of neovascularization in the course of the angiogenesis in endometriosis.The high expression of VEGF in eutopic endometrium of endometriosis also suggested that the special quality of the endometrium may be an essential condition in the development of endometriosis.