The expression levels and clinical significance of VEGF and nm23 in endometriosis

Objective:To explore the roles of vascular endothelial growth factor (VEGF) and non-metastasis 23 (nm23) in the genesis and development of endometriosis.Methods:The expression levels of VEGF and nm23 in ectopic endometrium of 40 patients with ovarian endometriosis,eutopic endometrium of 35 patients with ovarian endometriosis and normal endometrium of 30 healthy women were detected by immunohistochemistry.Results:The expression level of VEGF in ectopic endometrium was 82.5%,which was significantly higher than those in eutopic endometrium (62.8%) and normal endometrium (36.67%),there was significant difference between each other.The expression level of nm23 in ectopic endometrium was 42.5%,which was lower than those in eutopic endometrium (77.14%) and normal endometrium (93.33%),there was significant difference between ectopic endometrium and eutopic endometrium.There was no correlation between VEGF and nm23 in ectopic endometrium (γ=-0.136,P0.05).Conclusion:VEGF and nm23 play important roles in the genesis and development of endometriosis.