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2013•Unpublished venueRequires access

Determination of notoginsenoside R_1 and ginsenoside Rg_1、Rb_1 in Tongshu Capsules by HPLC

Zhang Yuan-jie

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Abstract

Objective To establish a method for determination of notoginsenoside R1 and ginsenoside Rg1,Rb1 in Tongshu Capsules by HPLC.Methods Waters Symmetry RP18(4.6 mm×250 mm,5 μm)column was used,with mixture liquid of acetonitrile and water as mobile phase in a gradient mode.The detection wavelength was 203 nm,the column temperature was 30 ℃,and the flow rate was 1.0 mL·min-1.Results The linear ranges of notoginsenoside R1 and ginsenoside Rg1,Rb1were 0.206~3.09 μg(r=0.999 4),0.882~13.23 μg(r=0.999 5),0.921~13.82 μg(r=0.999 2),the average recoveries(n=9)were 104.2%(RSD=0.77%),100.7%(RSD=1.1%),103.1%(2.1%),respectively.Conclusion The method was sensitive,accurate.It can be used for determination and quality control of Tongshu Capsules.

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Objective To establish a method for determination of notoginsenoside R1 and ginsenoside Rg1,Rb1 in Tongshu Capsules by HPLC.Methods Waters Symmetry RP18(4.6 mm×250 mm,5 μm)column was used,with mixture liquid of acetonitrile and water as mobile phase in a gradient mode.The detection wavelength was 203 nm,the column temperature was 30 ℃,and the flow rate was 1.0 mL·min-1.Results The linear ranges of notoginsenoside R1 and ginsenoside Rg1,Rb1were 0.206~3.09 μg(r=0.999 4),0.882~13.23 μg(r=0.999 5),0.921~13.82 μg(r=0.999 2),the average recoveries(n=9)were 104.2%(RSD=0.77%),100.7%(RSD=1.1%),103.1%(2.1%),respectively.Conclusion The method was sensitive,accurate.It can be used for determination and quality control of Tongshu Capsules.

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Available abstract

Objective To establish a method for determination of notoginsenoside R1 and ginsenoside Rg1,Rb1 in Tongshu Capsules by HPLC.Methods Waters Symmetry RP18(4.6 mm×250 mm,5 μm)column was used,with mixture liquid of acetonitrile and water as mobile phase in a gradient mode.The detection wavelength was 203 nm,the column temperature was 30 ℃,and the flow rate was 1.0 mL·min-1.Results The linear ranges of notoginsenoside R1 and ginsenoside Rg1,Rb1were 0.206~3.09 μg(r=0.999 4),0.882~13.23 μg(r=0.999 5),0.921~13.82 μg(r=0.999 2),the average recoveries(n=9)were 104.2%(RSD=0.77%),100.7%(RSD=1.1%),103.1%(2.1%),respectively.Conclusion The method was sensitive,accurate.It can be used for determination and quality control of Tongshu Capsules.

Key concepts: Ginsenoside Rg1, Chromatography, High-performance liquid chromatography, Chemistry, Ginsenoside, Medicine, Alternative medicine, Pathology

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